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Encellin: Targeting Chronic Diseases with Its Innovative Cell Encapsulation Technology Platform

Image Credits: Encellin
By: Headliners News / December 15, 2023

In the growing space of cutting-edge biotech innovations, Encellin, a Bay Area-based startup has emerged as a trailblazing force, securing a substantial $9.9 million in funding led by Khosla Ventures and backed by Y Combinator. Pioneering the frontier of therapeutic advancements, Encellin’s proprietary “cell encapsulation” technology takes center stage, unveiling a groundbreaking platform designed to administer years of cell therapy through a singular implant.

Founded on the groundbreaking research originating from Dr. Tejal Desai’s laboratory at the University of California in San Francisco, Encellin’s core mission revolves around perfecting nanofabricated membranes featuring meticulously defined pore structures. The result? The Encapsulated Cell Replacement Therapy (EnCRT), a revolutionary approach to combat endocrine disorders, with an initial focus on Type 1 diabetes and ambitious plans for Type 2 diabetes in the pipeline.

Encellin’s EnCRT platform, already greenlit for clinical trials, employs soft “nano-porous” pouches crafted from biocompatible materials. The objective is to shield therapeutic cells from the immune system, allowing them to function as “living medicine” by exchanging biomolecules with surrounding tissues. Essentially, it’s a symbiotic relationship, enhancing therapeutic benefits.

The EnCRT, a compliant polymeric implant constructed from proprietary nano-porous materials, holds the promise of minimally invasive implantation without triggering a foreign body response. This breakthrough potentially eliminates the need for immunosuppression, opening avenues for the transplantation of diverse therapeutic cell types.

Dr. Crystal Nyitray, the visionary CEO of Encellin, explained in a recent interview with Longevity.Technology, “Using advanced technologies in nanotechnology and bioengineering, we have developed biocompatible materials into permeable, soft pouches designed to support cell function.” Encellin’s preclinical data paints an optimistic picture, showcasing the potential to reverse Type 1 diabetes with no fibrosis or immune response, maintaining optimal cell viability and function.

Now, with their recent financing round, spearheaded by Khosla Ventures and complemented by Y Combinator, positions Encellin for a Phase 1 clinical trial. This trial will evaluate the subcutaneous transplantation of primary islets in Type 1 diabetes, with first-in-human data expected next year. Upon validation in the clinical setting, Encellin envisions expanding its repertoire to encompass more intricate therapies such as stem cells, gene therapy, and enzyme replacement therapy.

The transformative nature of Encellin’s approach, turning implanted cells into programmable molecular factories within the body. With an initial spotlight on Type 1 diabetes, Encellin’s technology holds the promise of delivering an extensive array of living medicines derived from engineered cells, showcasing the dawn of a new era in biotechnology.

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